FDA Data · GLP-1
Wegovy Reported Side Effects
semaglutide by Novo Nordisk. Approved 2021 for weight management.
17,958 total adverse event reports in FAERS
What are the most reported side effects of Wegovy?
These are the 15 most frequently reported adverse events for Wegovy in the FDA FAERS database. Higher counts mean more reports, not necessarily higher risk.
Nausea
2,432
Vomiting
1,695
Diarrhea
1,143
Fatigue
913
Constipation
774
Headache
712
Weight Increased
699
Dizziness
670
Decreased Appetite
603
Inappropriate Schedule Of Product Administration
587
Weight Loss
550
Abdominal Pain
504
Upper Abdominal Pain
492
Dyspnoea
489
Malaise
484
Side Effects by Category
Digestive9 reported side effects
| Nausea | 2,432 |
| Vomiting | 1,695 |
| Diarrhea | 1,143 |
| Constipation | 774 |
| Abdominal Pain | 504 |
| Upper Abdominal Pain | 492 |
| Indigestion | 311 |
| Delayed Stomach Emptying | 297 |
| Pancreatitis | 294 |
Other21 reported side effects
| Weight Increased | 699 |
| Inappropriate Schedule Of Product Administration | 587 |
| Dyspnoea | 489 |
| Pain | 478 |
| Illness | 460 |
| Injection Site Pain | 437 |
| Weight Loss Poor | 404 |
| Increased Appetite | 354 |
| Device Malfunction | 333 |
| Hunger | 331 |
| Wrong Technique In Product Usage Process | 314 |
| Fall | 305 |
| Injection Site Extravasation | 300 |
| Covid-19 | 291 |
| Injection Site Haemorrhage | 289 |
| Cough | 283 |
| Device Leakage | 270 |
| Acute Kidney Injury | 267 |
| Abdominal Discomfort | 249 |
| Product Communication Issue | 248 |
| Pyrexia | 243 |
Metabolic6 reported side effects
| Fatigue | 913 |
| Decreased Appetite | 603 |
| Weight Loss | 550 |
| Malaise | 484 |
| Dehydration | 411 |
| Weakness | 352 |
Neurological2 reported side effects
| Headache | 712 |
| Dizziness | 670 |
Mental Health3 reported side effects
| Anxiety | 432 |
| Depression | 366 |
| Insomnia | 277 |
Muscle & Joint3 reported side effects
| Joint Pain | 390 |
| Back Pain | 274 |
| Arm/Leg Pain | 252 |
How does Wegovy compare to other GLP-1 medications?
Frequently Asked Questions
Important: This data comes from the FDA Adverse Event Reporting System (FAERS), a voluntary reporting system. Report counts do not prove the medication caused the event. Not all adverse events are reported, and reporting rates vary by drug, time since approval, and media attention. This tool is for educational purposes only and is not medical advice. Always consult your healthcare provider about medication side effects.