FDA Data · GLP-1/GIP
Zepbound Reported Side Effects
tirzepatide by Eli Lilly. Approved 2023 for weight management.
43,290 total adverse event reports in FAERS
What are the most reported side effects of Zepbound?
These are the 15 most frequently reported adverse events for Zepbound in the FDA FAERS database. Higher counts mean more reports, not necessarily higher risk.
Nausea
4,112
Injection Site Pain
3,845
Extra Dose Administered
3,275
Accidental Underdose
2,502
Diarrhea
2,134
Vomiting
1,767
Injection Site Erythema
1,533
Injection Site Haemorrhage
1,447
Constipation
1,409
Fatigue
1,263
Therapeutic Response Changed
1,204
Injection Site Bruising
1,136
Injection Site Reaction
928
Weight Increased
928
Injection Site Pruritus
843
Side Effects by Category
Other27 reported side effects
| Injection Site Pain | 3,845 |
| Extra Dose Administered | 3,275 |
| Accidental Underdose | 2,502 |
| Injection Site Erythema | 1,533 |
| Injection Site Haemorrhage | 1,447 |
| Therapeutic Response Changed | 1,204 |
| Injection Site Bruising | 1,136 |
| Injection Site Reaction | 928 |
| Weight Increased | 928 |
| Injection Site Pruritus | 843 |
| Hunger | 612 |
| Illness | 598 |
| Accidental Overdose | 593 |
| Injection Site Rash | 559 |
| Abdominal Discomfort | 532 |
| Wrong Technique In Product Usage Process | 521 |
| Injection Site Injury | 518 |
| Injection Site Swelling | 466 |
| Pain | 456 |
| Injection Site Mass | 451 |
| Product Tampering | 412 |
| Feeling Abnormal | 374 |
| Product Storage Error | 370 |
| Product Administered At Inappropriate Site | 367 |
| Underdose | 359 |
| Injection Site Urticaria | 349 |
| Gastrointestinal Disorder | 341 |
Digestive11 reported side effects
| Nausea | 4,112 |
| Diarrhea | 2,134 |
| Vomiting | 1,767 |
| Constipation | 1,409 |
| Upper Abdominal Pain | 802 |
| Burping (Eructation) | 700 |
| Indigestion | 641 |
| Acid Reflux (GERD) | 471 |
| Abdominal Pain | 415 |
| Bloating | 402 |
| Flatulence | 344 |
Metabolic5 reported side effects
| Fatigue | 1,263 |
| Malaise | 430 |
| Decreased Appetite | 418 |
| Dehydration | 359 |
| Weakness | 355 |
Neurological2 reported side effects
| Headache | 833 |
| Dizziness | 696 |
Skin & Hair1 reported side effects
| Hair Loss | 752 |
How does Zepbound compare to other GLP-1 medications?
Frequently Asked Questions
Important: This data comes from the FDA Adverse Event Reporting System (FAERS), a voluntary reporting system. Report counts do not prove the medication caused the event. Not all adverse events are reported, and reporting rates vary by drug, time since approval, and media attention. This tool is for educational purposes only and is not medical advice. Always consult your healthcare provider about medication side effects.